Increased methacholine sensitivity after eucapnic voluntary hyperpnea

Findings In athletes with AHR, the PC20 (expressed as the mean of double concentrations (DC) ± standard error) was 0.7 ± 1.2 DC lower when MIT followed EVH (p = 0.015), while there was no significant difference in athletes without AHR (-0.4 ± 0.8 DC) nor in control subjects (0.4 ± 0.7 DC). When grouping subjects based on the EVH response, those with a positive response (FEV1 fall ≥ 10%) had a mean PC20 0.8 ± 1.1 DC lower when MIT followed EVH (p = 0.0008) while in those with no response to EVH (FEV1 fall <10%), airway responsiveness was not influenced by this test (0.05 ± 0.76 DC).